The experimental neurosis of albino rat caused by excessive training, (training seizure).

Some mental friction or sensory stimulation may put animals to peculiar movements or attitudes which are called experimental neurosis. On this subject numerous reports have been made since Maier (1, 1939). In experimental neurosis the loss or weakening of various reflexes is common. Hiwatari (3) found a deviation of eye balls due to the loss of rapid. phase and the remaining of slow phase of the rotatory nystagmus and he attributed this to the disturbances in cerebral cortex and brain stem. EEG, EMG and ECG in experimental neurosis were studies by Lindsley (5), Hiwatari and Tsukiyama (3) and recently by Sugi (9). Regarding the temperature of skin and brain during seizure, experiments were made by Sasaki (6) and these results were summulized by Yoshii (7). Authors have come to know that if an excessive exercise is applied repeatedly to albino rats, similar symptoms as those of experimental neurosis may occur. This should be called "Training seizure". Beside the observation of the symptoms of this seizure, investigations were made on changes in the weight of brain and the brain content of K and Na and also histological changes in the central nervous system.